Alignment of Metal Ions in Artificial Metallo-DNAs.
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Accession number;04A0258608
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| Title;Alignment of Metal Ions in Artificial Metallo-DNAs. |
| Author;
TANAKA KENTARO
(Univ. Tokyo, Graduate School, JPN)
TAKEZAWA YUSUKE
(Univ. Tokyo, Graduate School, JPN)
YORI MAIKO
(Univ. Tokyo, Graduate School, JPN)
TENGEIJI ATSUSHI
(Univ. Tokyo, Graduate School, JPN)
YAMADA YASUYUKI
(Univ. Tokyo, Graduate School, JPN)
SHIONOYA MITSUHIKO
(Univ. Tokyo, Graduate School, JPN)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.18th;NO.;PAGE.50-51(2003)
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| Figure&Table&Reference;FIG.1, REF.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;DNA is a promising molecule that provides a structural basis for the 'bottom-up' fabrication of inorganic and bioorganic constituents. Replacement of hydrogen-bonded base pairing of natural DNA by metal-mediated base pairing could lead to "metallo-DNA" in which metal ions are aligned along the helix axis in a predictable fashion. This strategy would be expanded to the regulation of thermodynamic stability of DNA structures as well as to discrete assembly of metal ions. Herein we report a discrete array of metal ions in a designed sequences programmed on the artificial DNA. We have synthesized an artificial oligonucleotide d(5'-GHPHC-3') which includes Cu2+ selective hydroxypyridone bearing-nucleosides, H, and a Hg2+ selective pyridine bearing-nucleoside, P. In the presence of stoichiometric amount of Cu2+ and Hg2+ ions to artificial base pairs, the oligomers form a double strand through H-Cu2+-H and P-Hg2+-P base pairing. In other words, two Cu2+ and one Hg2+ ions were assembled into the oligo duplex. (author abst.) |
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