Channel Structure Formation and Ion Selective Permeation by a Series of Artificial Ion Channels Based on Thiacalix[4]arene.
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Accession number;04A0258613
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| Title;Channel Structure Formation and Ion Selective Permeation by a Series of Artificial Ion Channels Based on Thiacalix[4]arene. |
| Author;
SHINJO HIROKO
(Nashidai In)
UEDA CHIHIRO
(Nashidai In)
OGAWA ASUKA
(Nashidai In)
SHIRAI NAOHIRO
(Nashidai In)
ODASHIMA KAZUNORI
(Nashidai In)
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Journal Title;Abstracts. Symposium on Biofunctional Chemistry
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Journal Code:L0836A
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ISSN:
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VOL.18th;NO.;PAGE.60-61(2003)
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| Figure&Table&Reference;FIG.3, REF.1 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;As a basic study for the development of artificial ion-channels with high structural stability, we designed and synthesized a series of half-channel molecules based on thiacalix[4]arene as a rigid skeleton (1-3, cone isomers). Their channel-forming activities were measured by a planar bilayer lipid membrane method with an applied potential of 100 mV, and the ion selectivities were examined for Li+, Na+, K+, Mg2+ and Ca2+ ions. Among a series of half channels with alkyl chains (1, 2), only those having appropriately long alkyl chains and nonhindered, hydrophilic thiacalix[4]arene structure showed distinct single channel pulse currents. Moreover, whereas the amide type 1 displayed K+ selective permeability, the ester type 2 showed stable single channel currents for Li+. Based on the complexation study, the K+ selective current by the former can be attributed to its selective complexation (blocking) with Li+ and Na+ ions. Half channel 3, equipped with hydrophilic oligoether chains, showed stable K+ selective channel currents. Single channel pulse currents with long open duration (>1 s) were observed more frequently for 3 with oligoether chains than for 1 and 2 with alkyl chains. (author abst.) |
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