Characterization of Hypoglycemic Effect of Mitiglinide Calcium Dihydrate(KAD-1229), a Novel Hypoglycemic Agent-Comparison with Glibenclamide, a Sulfonylurea-
|
Accession number;04A0309579
|
| Title;Characterization of Hypoglycemic Effect of Mitiglinide Calcium Dihydrate(KAD-1229), a Novel Hypoglycemic Agent-Comparison with Glibenclamide, a Sulfonylurea- |
| Author;
OJIMA KAZUMA
(Kissei Pharm. Co., Ltd.)
ICHIKAWA KIYOSHI
(Kissei Pharm. Co., Ltd.)
FUJIMORI YOSHIKAZU
(Kissei Pharm. Co., Ltd.)
AOYAGI IKUMI
(Kissei Pharm. Co., Ltd.)
YAMATO TOKUHISA
(Kissei Pharm. Co., Ltd.)
TSUJI ATSUTOSHI
(Kissei Pharm. Co., Ltd.)
KUSAMA HIROSHI
(Kissei Pharm. Co., Ltd.)
KOJIMA MASAMI
(Kissei Pharm. Co., Ltd.)
SHIBATA NOBUO
(Kissei Pharm. Co., Ltd.)
|
Journal Title;Japanese Pharmacology & Therapeutics
|
Journal Code:Z0947A
|
ISSN:0386-3603
|
|
VOL.32;NO.2;PAGE.65-72(2004)
|
| Figure&Table&Reference;FIG.5, TBL.1, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Objectives: The purpose of the present study was to characterize the hypoglycemic effect of mitiglinide calcium dihydrate (KAD-1229), a novel hypoglycemic agent, by comparison with that of glibenclamide, a sulfonylurea agent. Methods: Plasma glucose levels were measured in normal rats after administration of drugs either with a sucrose load (oral sucrose tolerance test) or with no load. In the case of the oral sucrose tolerance test, plasma insulin levels were also measured. Additionally, any changes in the hypoglycemic effects of the two drugs in diabetic rats were assessed during repeated oral administration for 4 weeks. Results: The hypoglycemic effect of mitiglinide calcium dihydrate (0.3 and 1mg/kg) was evident sooner after its administration, and was briefer, than that of glibenclamide (1 and 3mg/kg). The rate of increase in insulin release was faster in the mitiglinide group than in the glibenclamide group. The hypoglycemic effect of glibenclamide (1 and 3mg/kg) declined as the period of repeated administration increased. On the other hand, the effect of mitiglinide calcium dihydrate at 1mg/kg was maintained, and even though a decline was observed at 3mg/kg, its extent was less than that seen with glibenclamide (1 and 3mg/kg). Conclusion: Mitiglinide was found to have a hypoglycemic effect that begins sooner and is shorter lasting than that of glibenclamide. This is probably due to its faster insulinotropic effect. Moreover, mitiglinide seemed hardly to induce secondary failure, at least compared with glibenclamide. (author abst.) |
|
|
|
Related Articles;
|
|
