Rapid Onset-Insulinotropic Effect of Mitiglinide Calcium Dihydrate(KAD-1229), a Novel Antipostprandial Hyperglycemic Agent-Comparison with Nateglinide-
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Accession number;04A0309580
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| Title;Rapid Onset-Insulinotropic Effect of Mitiglinide Calcium Dihydrate(KAD-1229), a Novel Antipostprandial Hyperglycemic Agent-Comparison with Nateglinide- |
| Author;
OJIMA KAZUMA
(Kissei Pharm. Co., Ltd.)
ICHIKAWA KIYOSHI
(Kissei Pharm. Co., Ltd.)
FUJIMORI YOSHIKAZU
(Kissei Pharm. Co., Ltd.)
AOYAGI IKUMI
(Kissei Pharm. Co., Ltd.)
YAMATO TOKUHISA
(Kissei Pharm. Co., Ltd.)
TSUJI ATSUTOSHI
(Kissei Pharm. Co., Ltd.)
KUSAMA HIROSHI
(Kissei Pharm. Co., Ltd.)
KOJIMA MASAMI
(Kissei Pharm. Co., Ltd.)
SHIBATA NOBUO
(Kissei Pharm. Co., Ltd.)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.32;NO.2;PAGE.73-80(2004)
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| Figure&Table&Reference;FIG.5, TBL.2, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Objectives: The purpose of the present study was to evaluate the insulinotropic effect of mitiglinide calcium dihydrate (KAD-1229), a novel antipostprandial hyperglycemic agent, by comparison with that of nateglinide. Methods: Mitiglinide calcium dihydrate or nateglinide was administered orally just before an oral-sucrose or liquid-meal load in normal rats, and in mild, moderate, or severe streptozotocin-injected diabetic rats. The plasma insulin and glucose levels were measured. Results: Mitiglinide calcium dihydrate (1mg/kg) and nateglinide (50 mg/kg) decreased the plasma glucose levels significantly at 15-120 min and 15-60 min, respectively in normal rats, and at 30-90 min and 30-60 min, respectively, in mildly diabetic rats. These drugs increased the plasma insulin levels at 5-45 min and 5-15 min, respectively, in normal rats, and at 15-60 min and 15-45 min, respectively, in mildly diabetic rats. In moderately diabetic rats, the antihyperglycemic effects of mitiglinide calcium dihydrate (1 and 3 mg/kg) and nateglinide (50 and 100 mg/kg) were evident at 30-120 min and 30-60 min, respectively. In the same rats, mitiglinide, but not nateglinide, significantly increased the plasma insulin levels at 30min after its administration. Mitiglinide also exhibited antihyperglycemic and insulinotropic effects in the severely diabetic rats. Conclusion: Mitiglinide and nateglinide are suitable drugs for controlling postprandial hyperglycemia. Their antihyperglycemic effects were probably secondary to their rapid-onset, short-lasting insulinotropic effects, and mitiglinide seemed to be a more potent rapid-onset insulinotropic drug than nateglinide. (author abst.) |
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