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Accession number;04A0344799
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| Title;Effects of Brinzolamide on Ocular Blood Flow in Normal-Tension Glaucoma |
| Author;
EMI KAZUO
(Emiganka)
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Journal Title;Journal of the Eye
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Journal Code:Y0754A
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ISSN:0910-1810
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VOL.21;NO.4;PAGE.535-538(2004)
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| Figure&Table&Reference;FIG.6, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The effects of brinzolamide on orbital hemodynamics were investigated by color Doppler imaging in 20 normal-tension glaucoma (NTG) patients, using the LOGIQ500 color Doppler unit (GE Medical System) with 6.5MHz linear phased array transducer. The central retinal artery (CRA) and short posterior ciliary artery (PCA) were examined to assess the peak systolic, mean and end-diastolic velocity of both vessels before and at two weeks of brinzolamide usage. The resistive index was calculated from above parameters, as an indicator of peripheral vascular resistance. CRA end-diastolic blood flow velocity increased after the use of brinzolamide (p=0.03), and CRA resistive index decreased (p=0.01), though brinzolamide failed to change PCA flow velocity or resistive index. Brinzolamide significantly reduced intraocular pressure at two weeks (p=0.0001) and improved CRA hemodynamics, as related to reduction in either intraocular pressure or CRA peripheral vascular resistance. (author abst.) |
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