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Accession number;04A0344805
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| Title;Influence of Vitamin C on Oxidative Stress in the Eyeball |
| Author;
SAKAI MISAKO
(Showadai I Daiichiseirigaku)
HISAMITSU NAOKO
(Showadai I Daiichiseirigaku)
OMORI TAKASHI
(Showadai I Daiichiseirigaku)
ASAHINA SHIGERU
(Showadai I Daiichiseirigaku)
EGURO TAKESHI
(Showadai I Daiichiseirigaku)
HISAMITSU TADASHI
(Showadai I Daiichiseirigaku)
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Journal Title;Journal of the Eye
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Journal Code:Y0754A
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ISSN:0910-1810
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VOL.21;NO.4;PAGE.559-563(2004)
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| Figure&Table&Reference;FIG.5, REF.22 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The influence of vitamin C on oxidative stress in eyeball was examined using mice stressed by water-immersion restraint. Male BALB/c mice, 5 weeks of age, were subjected to water-immersion restraint stress for 8 hours at 25.DEG.C.. Oxidative stress in the eyeball was assessed by examining the contents of both lipid peroxide and vitamin C. Intraperitoneal injection of vitamin C significantly suppressed eyeball lipid peroxide generation, which was increased by water-immersion restraint stress. Pretreatment with vitamin C also prevented the decrease in eyeball content of vitamin C, but not vitamin E, resulting from water-immersion restraint stress. We then examined the influence of vitamin C on nitroxide radical disappearance from the mouse eyeball. The stress caused significant reduction in radical intensity, which reduction was prevented by pretreatment with vitamin C. These results strongly suggest that vitamin C can suppress superoxide generation, preventing oxidative stress in the eyeball. (author abst.) |
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