Positive Relationship between Androgen and the Endocrine Disruptor, Bisphenol A, in Normal Women and Women with Ovarian Dysfunction
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Accession number;04A0381477
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| Title;Positive Relationship between Androgen and the Endocrine Disruptor, Bisphenol A, in Normal Women and Women with Ovarian Dysfunction |
| Author;
TAKEUCHI T
(Univ. Tokyo, Tokyo, Jpn)
TSUTSUMI O
(Univ. Tokyo, Tokyo, Jpn)
IKEZUKI Y
(Univ. Tokyo, Tokyo, Jpn)
TAKAI Y
(Univ. Tokyo, Tokyo, Jpn)
TAKETANI Y
(Univ. Tokyo, Tokyo, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.51;NO.2;PAGE.165-169(2004)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.19 |
| Pub. Country;Japan |
| Language;English |
| Abstract;This study was performed to investigate the serum levels of bisphenol A (BPA), an endocrine disruptor, in women with ovarian dysfunction and obesity. Fasting serum samples were obtained from 19 non-obese and 7 obese women with normal menstrual cycles: 7 patients with hyperprolactinemia, 21 patients with hypothalamic amenorrhea, and 13 non-obese and 6 obese patients with polycystic ovary syndrome (PCOS). BPA was measured by an enzyme-linked immunosorbent assay. BPA was detected in all human sera. Serum BPA concentrations were significantly higher in both non-obese and obese women with polycystic ovary syndrome (1.05.+-.0.10ng/ml, 1.17.+-.0.16ng/ml; p<0.05, respectively) and obese normal women (1.04.+-.0.09ng/ml, p<0.05) compared with those in non-obese normal women (0.71.+-.0.09ng/ml). There was no difference among women with hyperprolactinemia, women with hypothalamic amenorrhea, and non-obese normal women. There were significant positive correlations between serum BPA and total testosterone (r=0.391, p<0.001), free testosterone (r=0.504, p<0.001), androstenedione (r=0.684, p<0.001), and DHEAS (r=0.514, p<0.001) concentrations in all subjects. These findings show that there is a strong relationship between serum BPA and androgen concentrations, speculatively due to the effect of androgen on the metabolism of BPA. (author abst.) |
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