Highly Effective Method for Collecting Autologous Peripheral Stem Cells from Patients with Multiple Myeloma
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Accession number;04A0314143
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| Title;Highly Effective Method for Collecting Autologous Peripheral Stem Cells from Patients with Multiple Myeloma |
| Author;
YASUDA MASAHIRO
(Gifu Municipal Hospital, JPN)
SAKAIDA MASAMITSU
(Gifu Municipal Hospital, JPN)
KATO HIROAKI
(Gifu Municipal Hospital, JPN)
YOKOYAMA YUKO
(Gifu Municipal Hospital, JPN)
TANAHASHI JUNKO
(Gifu Municipal Hospital, JPN)
SHIMOMURA YORIKO
(Gifu Municipal Hospital, JPN)
TAKAHASHI TAKESHI
(Gifu Municipal Hospital, JPN)
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Journal Title;Japanese Journal of Pharmaceutical Health Care and Sciences
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Journal Code:Y0888A
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ISSN:1346-342X
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VOL.30;NO.4;PAGE.280-287(2004)
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| Figure&Table&Reference;TBL.6, REF.38 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We investigated a highly effective method for collecting a sufficient quantity of autologous peripheral stem cells from patients with multiple myeloma in a single attempt. Eight patients (5 males and 3 females, mean age: 56.5 years) underwent remission-induction chemotherapy (built around a VAD regimen), followed by mobilization chemotherapy using cyclophosphamide (CPA 2 g/m2 given for 2 days, 7 patients) or etoposide (VP-16,500 mg/m2 for 3 days, one patient). When the leukocyte count dropped below 1,000/.MU.L, a granulocyte colony stimulating factor, lenograstim (7.1.+-.2.9.MU.g/kg/day), was administered for around 7 days. When the leukocyte count exceeded 104/.MU.L, stem cells were collected by processing the blood in a fluid having a volume of three times that of circulating blood and using a COBE Spectra, a blood component separating device. The required number of hematopoietic stem cells (CD 34+cells, over 2.0*106/kg) was obtained from 6 patients in a single operation (within 4 hours). From 5 of them, a sufficient quantity was obtained for tandem grafting. Through adequate drug monitoring from the standpoint of a pharmacist, no severe adverse effects that would have necessitated interrupting the cell collecting procedure occurred. (author abst.) |
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