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Accession number;04A0411201
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| Title;Influence of Flecainide Acetate on Herpetic Pain in Mice Infected with Herpes Simplex Virus |
| Author;
ASANO KAZUHITO
(Showadai I Daiichiseirigaku)
SAMESHIMA TATSUO
(Showadai I Daiichiseirigaku)
ASAHINA SHIGERU
(Showadai I Daiichiseirigaku)
SAKAI MISAKO
(Showadai I Daiichiseirigaku)
OMORI TAKASHI
(Showadai I Daiichiseirigaku)
OSHITA YUSUKE
(Showadai I Daiichiseirigaku)
HISAMITSU TADASHI
(Showadai I Daiichiseirigaku)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.32;NO.3;PAGE.169-174(2004)
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| Figure&Table&Reference;FIG.5, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The influence of flecainide acetate (FA) on herpes-related pain responses was examined using mice infected with herpes simplex virus (HSV). BALB/c mice inoculated with HSV on the hind paw showed decrease in nociceptive threshold, which appeared in the hind paw on the inoculated side on day 6. Intraperitoneal adminstration of FA, a human injection grade, prevented decrease in nociceptive threshold dose-dependently in HSV-inoculated mice, which was firstly observed at a dose of 75mg/kg, and peaked at doses more than 100mg/kg. This antinociceptive effect of FA was attained peak at 60 min after administration and declined gradually to non-treated levels by 180 min. Intraperitoneal administration of FA at a dose of 100mg/kg caused significant increase in .BETA.-endorphin (BE) levels in mid brain and hypothalamus from HSV-inoculated mice. These results strongly suggest that FA exerts antinociceptive effects on herpes-related pain through enhancement of BE levels in central nerveous system in HSV-inoculated mice. (author abst.) |
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