Tumor Necrosis Factor-.ALPHA. in Tears of Patients with Sjoegren Syndrome
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Accession number;04A0415636
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| Title;Tumor Necrosis Factor-.ALPHA. in Tears of Patients with Sjoegren Syndrome |
| Author;
OSHIDA TAIKI
(School of Medicine, Nihon Univ., JPN)
IWATA MITSUHIRO
(School of Medicine, Nihon Univ., JPN)
SAKIMOTO TAKASHI
(School of Medicine, Nihon Univ., JPN)
SAWA MITSURU
(School of Medicine, Nihon Univ., JPN)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.108;NO.5;PAGE.297-301(2004)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.30 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To determine the pathological role of tumor necrosis factor alpha (TNF-.ALPHA.) in ocular surface disorder of patients with Sjoegren syndrome (SS), TNF-.ALPHA. in the tears of patients with SS were analyzed. In addition, the relationship between TNF-.ALPHA. levels in the tear samples and the severity of the corneal epithelial disorder was evaluated. Material and Methods: Tear samples were obtained from the 60 eyes of 30 patients with primary SS and the 60 eyes of 30 normal subjects. Tear samples were analyzed using a sandwich enzymelinked immunosorbent assay to detect TNF-.ALPHA.. Corneal epithelial cell damage was examined with a slit-lamp biomicroscope and scored by the van Bijsterveld scoring system. Results: TNF-.ALPHA. was detected in the tears of patients with SS at concentrations ranging from 8 to 1,500 pg/ml in 33 of the 60 eyes of the patients. In contrast, TNF-.ALPHA. was not detected in the tears of normal controls. The concentration of TNF-.ALPHA. was significantly higher in the tear samples from patients whose clinical scores were two or three points compared with patients whose scores were zero or one point (Mann-Whitney U test: p<0.03). Conclusions: TNF-.ALPHA. was detected in the tears of patients with SS, and tear TNF-.ALPHA. levels showed a significant correlation with the grade of corneal epithelial damage, suggesting that TNF-.ALPHA. is a potent mediator in keratoconjunctivitis sicca. (author abst.) |
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