Assessment of Retention and Drug-release of Ophthalmic Ointment on the Ocular Surface
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Accession number;04A0415638
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| Title;Assessment of Retention and Drug-release of Ophthalmic Ointment on the Ocular Surface |
| Author;
TAKAOKA MAHO
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
YOKOI NORIHIKO
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
ISHIBASHI TAKESHI
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
KINOSHITA SHIGERU
(Kyoto Prefect. Univ. of Med. Fac. of Med.)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.108;NO.5;PAGE.307-311(2004)
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| Figure&Table&Reference;FIG.2, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: The dynamics of ophthalmic ointment on the ocular surface were investigated using a fluorescent ointment. Methods: Ten healthy volunteers were enrolled. Ointment (1.0 cm length, 0.05g) containing 0.1% flavin adenine dinucleotide sodium was squeezed out from the tube and placed in the left lower conjunctival sac. The eyes were then closed for 30 seconds and permitted to blink naturally. Two examinations including observation of tear film lipid layer interference pattern and fluorophotometric measurement of fluorescence intensity, both at the center of the cornea, were performed before examination and at 1, 3, 6, 9, 12, 15, 30, 60 minutes after instillation. Results: In all cases, even 1 hour after installation, tear film interference patterns were observed, and fluorescence intensity greater than before installation, was present. Conclusion: Ointment placed in the conjunctival sac is thought to remain and release agents on the ocular surface for at least one hour. (author abst.) |
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