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Accession number;04A0414349
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| Title;Effectiveness of Bunazosin Hydrochloride in Patients Treated with Latanoprost and Beta-Blockers |
| Author;
KATSUSHIMA HARUMI
(Katsushimashika(sapporoshi))
YOSHIKAWA KEIJI
(Yoshikawaganka)
YAMABAYASHI SHIGEKI
(Yamabayashiganka Dai2ganka)
YAMAGISHI KAZUYA
(Hirakatayamagishiganka)
KIMURA TAIRO
(Uenogankaiin)
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Journal Title;Journal of the Eye
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Journal Code:Y0754A
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ISSN:0910-1810
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VOL.21;NO.5;PAGE.675-677(2004)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Bunazosin hydrochloride is a new selective .ALPHA.1-adrenergic antagonist developed to reduce intraocular pressure in glaucoma. We retrospectively evaluated the effectiveness of 0.01% bunazosin hydrochloride ophthalmic solution for l year in primary open-angle glaucoma patients who responded poorly to latanoprost and beta-blockers. Bunazosin was added to 12 eyes of 12 patients (additional therapy group) and replaced beta-blockers in 10 eyes of 10 patients (replacement therapy group). The additional therapy group showed significant intraocular pressure reduction from baseline (19.0.+-.3.6 mmHg, n=12) to 16.1.+-.3.0 mmHg (n=7, 13.3% reduction; p<0.02). In the replacement therapy group, intraocular pressure changed only slightly, from 17.9.+-.3.2 mmHg (n=10) to 16.1.+-.3.8 mmHg (n=7, not significant). None of the patients showed adverse effects from bunazosin. Bunazosin has an additive effect of lowering intraocular pressure in patients already receiving combination therapy of latanoprost (author abst.) |
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