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Accession number;04A0438538
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| Title;Chemical and Biological Studies of Bacterial Glycoconjugates as Key Substances of Innate Immunity |
| Author;
FUKASE KOICHI
(Osaka Univ., Grad. Sch.)
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Journal Title;Nippon Kagakkai Koen Yokoshu
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Journal Code:S0493A
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ISSN:0285-7626
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VOL.84th;NO.1;PAGE.A.5(2004)
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| Figure&Table&Reference;FIG.2, REF.3 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Bacterial peptidoglycan (PGN) and lipopolysaccharide have been well known as a strong immunopotentiator. PGN partial structures, e.g., tetra- and octasaccharide fragments having dipeptide moieties, were synthesized in order to elucidate the interaction of PGN with the receptor candidates. Muramyl dipeptide (MDP), which was previously identified as a minimal structure for immunostimulating activity of PGN, and other synthetic partial structures showed the activity via the intracellular protein NOD2, indicating NOD2 is the intracellular receptor for PGN. NOD1 mediated the recognition of PGN of Gram-negative bacteria and the core structure recognized by NOD1 was .GAMMA.-D-glutamyl-meso-diaminopimelic acid. The lipid part termed lipid A is a bioactive principle of lipopolysaccharide. Both acidic functional groups and acyl moieties in lipid A proved to be crucial for expression of the activity. We also demonstrated that lipid A and lipopolysaccharide directly interact with the receptor complex TLR4/MD2. (author abst.) |
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