Diagnostic Value of Interleukin-10 and Interleukin-6 in the Vitreous of Intraocular Malignant Lymphoma Patients
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Accession number;04A0488753
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| Title;Diagnostic Value of Interleukin-10 and Interleukin-6 in the Vitreous of Intraocular Malignant Lymphoma Patients |
| Author;
HIRAKATA AKITO
(School of Medicine, Kyorin Univ., JPN)
INAMI TATSUYA
(School of Medicine, Kyorin Univ., JPN)
SAITO MAKI
(Sch. of Med., Keio Univ.)
OKADA ANABERUAYAME
(School of Medicine, Kyorin Univ., JPN)
HIDA TETSUO
(School of Medicine, Kyorin Univ., JPN)
ISHIDA SUSUMU
(Sch. of Med., Keio Univ.)
SHINODA KEI
(Sch. of Med., Keio Univ.)
HOMORI MASASHI
(Kyorin Univ., School of Medicine, JPN)
KAWANO KOICHI
(Kyorin Univ., School of Medicine, JPN)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.108;NO.6;PAGE.359-367(2004)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.33 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Objective: Recent data suggest that the concentration of interleukin-10 (IL-10) is higher than that of interleukin-6 (IL-6) in the vitreous of eyes of patients with non-Hodgkin's lymphoma. In this study, we evaluated the utility of measuring intravitreal IL-10 and IL-6 concentrations in the diagnosis of intraocular lymphoma. Methods: Specimens of undiluted vitreous were collected at the time of pars plana vitrectomy and IL-10 and IL-6 concentrations were determined. Vitreous specimens were obtained from 5 patients with suspected intraocular lymphoma and 10 patients with uveitis presumed to be unrelated to a neoplasm. Results: In all 5 patients eventually diagnosed with intraocular lymphoma, the vitreous IL-10 concentration ranged from 3,040 to 11,200 pg/ml, and was higher than the vitreous IL-6 concentration in all cases. In 9 of the 10 patients with uveitis, the vitreous IL-10 concentrations ranged from less than 2 to 97 pg/ml, with an IL-10/IL-6 ratio of less than 0.11. However, in the remaining case diagnosed as uveitis of unknown etiology, the vitreous IL-10/IL-6 ratio was greater than 1. Conclusion: Our data suggest that the measurement of vitreous IL-10 concentrations would aid in the diagnosis of intraocular lymphoma. (author abst.) |
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