Serum Levels of 20 Kilodalton Human Growth Hormone (20K-hGH) in Patients with Acromegaly before and after Treatment with Octreotide and Transsphenoidal Surgery
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Accession number;04A0523041
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| Title;Serum Levels of 20 Kilodalton Human Growth Hormone (20K-hGH) in Patients with Acromegaly before and after Treatment with Octreotide and Transsphenoidal Surgery |
| Author;
MURAKAMI Y
(Shimane Univ., Izumo, Jpn)
SHIMIZU T
(Shimane Univ., Izumo, Jpn)
YAMAMOTO M
(Shimane Univ., Izumo, Jpn)
KATO Y
(Shimane Univ., Izumo, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.51;NO.3;PAGE.343-348(2004)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Circulating human GH (hGH) consists of several molecular isoforms. It was previously reported that the proportion of 20 kilodalton hGH (20K-hGH) was elevated in the serum of patients with active acromegaly. In this study, we investigated the effects of octreotide and transsphenoidal adenomectomy on the proportion of 20K-hGH in the serum of 7 acromegalic patients. To achieve an acute effect, octreotide (100 .MU.g) was subcutaneously injected as a bolus. To observe the chronic effects of octreotide therapy and surgery, serum samples were obtained by repetitive blood sampling before and 3 to 8 weeks after treatment. Serum levels of 20K-hGH and 22 kilodalton hGH (22K-hGH) were determined by specific enzyme-linked immunosorbent assay. A bolus injection of octreotide elicited a parallel decrease in serum 22K-hGH and 20K-hGH, resulting in an unchanged proportion of 20K-hGH to total circulating hGH. The proportion of 20K-hGH was decreased in 4 of 4 patients 4 to 7 weeks after surgery and in 2 of 4 patients after chronic treatment with octreotide for 3 to 8 weeks. The proportion of serum 20K-hGH was positively related to mean serum 20K-hGH as well as serum total hGH levels, but not with serum IGF-I levels. These findings suggest that high serum levels of 20K-hGH or total hGH per se might elicit a chronic change in the clearance kinetics of 20K-hGH and increase the proportion of 20K-hGH in acromegalic patients. (author abst.) |
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