Inhibitory effects of lysine analogue tranexamic acid on collagen degradation in inflamed gingival tissue.
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Accession number;04A0548692
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| Title;Inhibitory effects of lysine analogue tranexamic acid on collagen degradation in inflamed gingival tissue. |
| Author;
KIGAWA MARI
(Lion Corp., JPN)
KATAOKA SHINSUKE
(Lion Corp., JPN)
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Journal Title;Fragr J
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Journal Code:G0987B
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ISSN:0288-9803
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VOL.32;NO.7;PAGE.26-31(2004)
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| Figure&Table&Reference;FIG.8, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In this study, we evaluated the effect of the lysine analogue tranexamic acid (TXA), an inhibitor of plasmin, on gingival inflammation. We used a hamster gingival inflammation model to investigate collagen degradation and plasmin localization in gingiva. TXA (15 mg/body) or placebo was administered orally once daily for 3 weeks. To investigate collagen degradation of hamster gingiva, urinary collagen N-terminal peptide (NTx) was measured at once a week. There was a significant reduction of the urinary NTx level in the TXA group at week (P < 0.05), but no significant differences were detected at week 2 and 3. To determine whether MMP and plasmin were associated with the gingival inflammation, histological studies, film-zymography and immunofluorescence staining, were performed. Upregulation of MMP activity was observed in the inflamed gingival tissue. Although plasmin was strongly stained in the all sections of inflamed gingival tissue in the placebo group, plasmin was localized around vessels in the TXA group. In addition, we also found that TXA reduced the fMLP-induced neutrophil chemotaxis in a dose-dependent manner. These results suggest that TXA inhibits the collagen degradation of inflamed gingiva by controlling the plasmin related MMP activation pathways and prevents gingival inflammation by reducing the neutrophil migration rate. (author abst.) |
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