Renal Vascular Resistance and Renin-Angiotensin System in the Pathogenesis of Early Hypertension in Autosomal Dominant Polycystic Kidney Disease
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Accession number;04A0398527
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| Title;Renal Vascular Resistance and Renin-Angiotensin System in the Pathogenesis of Early Hypertension in Autosomal Dominant Polycystic Kidney Disease |
| Author;
RAMUNNI A
(Univ. Bari, Ita)
SARACINO A
(Univ. Bari, Ita)
ESPOSITO T
(Univ. Bari, Ita)
SALIANI M T
(Univ. Bari, Ita)
CORATELLI P
(Univ. Bari, Ita)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.4;PAGE.221-225(2004)
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| Figure&Table&Reference;FIG.1, TBL.1, REF.24 |
| Pub. Country;Japan |
| Language;English |
| Abstract;In order to examine the relation among renal vascular resistance, renin angiotensin system (RAS) and blood pressure in autosomal dominant polycystic kidney disease, continuous blood pressure measurements were performed over 24 hours on 34 patients with autosomal dominant polycystic kidney disease without renal disturbance, and the patients were divided into hypertension group of 17 (A group) and normal blood pressure group of 17 (B group) and renal vascular resistance and RAS were compared. As the result, the renal vascular resistance was significantly larger in A group than in B group. Plasma renin activity was normal in all patients and there was no significant difference between A group and B group. As a whole, though there was a significant positive correlation between renal vascular resistance and average arterial pressure over 24 hours, there were recognized no correlation between renal vascular resistance and plasma renin activity, as well as between average arterial pressure over 24 hours and plasma renin activity. From the above, it is suggested that factors other than RAS might contribute to increase of renal vascular resistance and early hypertension in the patient with autosomal dominant polycystic kidney disease without renal disturbance. |
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