Greater Change of Orthostatic Blood Pressure Is Related to Silent Cerebral Infarct and Cardiac Overload in Hypertensive Subjects
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Accession number;04A0398529
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| Title;Greater Change of Orthostatic Blood Pressure Is Related to Silent Cerebral Infarct and Cardiac Overload in Hypertensive Subjects |
| Author;
EGUCHI K
(Jichi Medical School, Tochigi, Jpn)
KARIO K
(Jichi Medical School, Tochigi, Jpn)
HOSHIDE S
(Jichi Medical School, Tochigi, Jpn)
HOSHIDE Y
(Jichi Medical School, Tochigi, Jpn)
ISHIKAWA J
(Jichi Medical School, Tochigi, Jpn)
MORINARI M
(Jichi Medical School, Tochigi, Jpn)
HASHIMOTO T
(Jichi Medical School, Tochigi, Jpn)
SHIMADA K
(Jichi Medical School, Tochigi, Jpn)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.4;PAGE.235-241(2004)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.33 |
| Pub. Country;Japan |
| Language;English |
| Abstract;In order to seek the clinical significance of orthostatic blood pressure change, 59 patients with hypertension were divided into 16 patients with orthostatic hypertension (A group), 18 patients with orthostatic hypotension (B group), and 25 patients with orthostatic normal blood pressure (C group) and brain MRI observations and neurohumoral factor were mainly compared. Ad the result, the plasma concentration of BNP (brain natriuretic peptide) and the ratio of BNP/ANP (atrial natriuretic peptide) were significantly greater in B group than in healthy control group (normal blood pressure group). The ratio of BNP/ANP was significantly greater in A group than in healthy control group. The number of asymptomatic cerebral infarction, morbidity of asymptomatic cerebral infarction and number of multiple asymptomatic cerebral infarction were the largest in A group, followed by B group, C group and healthy control group. There was no significant difference among A, B and C groups in blood pressure and LV myocardial weight index. From the above, it is suggested that orthostatic hypotension and orthostatic hypertension in hypertensive patients might increase the risk of asymptomatic cerebral infarction and heart overload. |
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