Amlodipine and Carvedilol Prevent Cytotoxicity in Cortical Neurons Isolated from Stroke-Prone Spontaneously Hypertensive Rats
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Accession number;04A0398534
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| Title;Amlodipine and Carvedilol Prevent Cytotoxicity in Cortical Neurons Isolated from Stroke-Prone Spontaneously Hypertensive Rats |
| Author;
YAMAGATA K
(Univ. Shizuoka, Shizuoka, Jpn)
ICHINOSE S
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
TAGAMI M
(Sanraku Hospital, Tokyo, Jpn)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.4;PAGE.271-282(2004)
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| Figure&Table&Reference;FIG.11, REF.42 |
| Pub. Country;Japan |
| Language;English |
| Abstract;In order to examine effects of an antihypertensive drug and vitamin E on the cell death of neurons, vitamin E or an antihypertensive drug was applied to cortical neurons in the title provided with oxygen (20% oxygen) after low oxygen load (1% oxygen) and cell survival and the like were examined in vitro by electron microscopy, etc. As the results, there was recognized a significant protecting effect on the cell, when vitamin E was applied between the low oxygen loading and the oxygen provision. And when the pretreatment with amlodipine, carvediol or dipyridamole was performed, the cell death was prevented continuously under the conditions of low oxygen and oxygen provision. Vitamin E had the strongest nerve protective effect, followed by dipyridamole, carvediol and amlodipine in order of decreasing. From the above, there seemed to be a possibility that amlodipine and carvediol having an antioxidative and antihypertensive action help the prevention of the cell death of neurons during the treatment of stroke and neurodegenerative disease of the hypertensive patient. |
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