Telomere Attrition in White Blood Cell Correlating with Cardiovascular Damage
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Accession number;04A0428314
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| Title;Telomere Attrition in White Blood Cell Correlating with Cardiovascular Damage |
| Author;
NAKASHIMA H
(Hiroshima Univ. Graduate School Of Biomedical Sci., Hiroshima, Jpn)
OZONO R
(Hiroshima Univ. Graduate School Of Biomedical Sci., Hiroshima, Jpn)
SUYAMA C
(Hiroshima Univ. Graduate School Of Biomedical Sci., Hiroshima, Jpn)
SUEDA T
(Hiroshima Univ. Graduate School Of Biomedical Sci., Hiroshima, Jpn)
KAMBE M
(Hiroshima Univ. Graduate School Of Biomedical Sci., Hiroshima, Jpn)
OSHIMA T
(Hiroshima Univ. Graduate School Of Biomedical Sci., Hiroshima, Jpn)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.5;PAGE.319-325(2004)
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| Figure&Table&Reference;FIG.5, TBL.2, REF.25 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The examination was made if the leucocyte telomere length became a marker for the biological aging of the cardiovascular system. Leucocyte telomere restriction fragment length (TRFL) was measured for those who had and those who didn't have risk factors of cardiovascular system (hypertension, hyperlipemia, diabetes mellitus) and diseases (coronary artery disease, peripheral artery disease, cerebrovascular disease). TRFL correlated with the age, and the TRFL of those who had cardiovascular system risk factor/disease was shorter than that estimated from the age. Accumulated score of cardiovascular system damage (CVD) showed significantly negative correlation with capillary endothelium function evaluated by the blood flow intermediate expansion. The accumulated CVD score showed significantly negative correlation with the ratio of TRFL measured value for normal TRFL estimated from TRFL and age and sex of the objects. The leucocyte telomere length was shortened in parallel with the depression of endothelial function and cardiovascular system damage, and it was indicated that it would become a marker for the biological aging of the cardiovascular system. |
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