Ultrasound Evaluation of Valsartan Therapy for Renal Cortical Perfusion
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Accession number;04A0428318
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| Title;Ultrasound Evaluation of Valsartan Therapy for Renal Cortical Perfusion |
| Author;
KISHIMOTO N
(Kansai Medical Univ., Osaka, Jpn)
MORI Y
(Kansai Medical Univ., Osaka, Jpn)
NISHIUE T
(Kansai Medical Univ., Osaka, Jpn)
NOSE A
(Kansai Medical Univ., Osaka, Jpn)
KIJIMA Y
(Kansai Medical Univ., Osaka, Jpn)
TOKORO T
(Kansai Medical Univ., Osaka, Jpn)
YAMAHARA H
(Kansai Medical Univ., Osaka, Jpn)
OKIGAKI M
(Kansai Medical Univ., Osaka, Jpn)
KOSAKI A
(Kansai Medical Univ., Osaka, Jpn)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.5;PAGE.345-349(2004)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.24 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The change in renal cortical perfusion to be induced by an angiotensin II type 1 receptor blockade medicine valsartan was examined for 7 healthy subjects using contrast media harmonic ultrasonic testing (CEHU). Though arterial pressure and pulse number were not changed by oral administration of valsartan 80mg, the renal blood plasma flow rate and renal blood flow rate evaluated by p-aminohippuric acid clearance increased significantly. The glomerular filtration rate evaluated by the thiosulfuric acid clearance did not increase, and the filtering rate decreased a little. The renal vascular resistance lowered significantly. The minute bubble speed increased at 2.3 times in CEHU after the administration of valsartan, the blood vessel volume did not change. The changes in minute bubble speed and blood perfusion in CEHU showed positive correlation with the renal blood flow. It was shown that valsartan increased human renal cortical blood flow mainly by the rise in blood flow velocity and that the renal cortical perfusion was able to be evaluated by CEHU. |
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