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Accession number;04A0428319
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| Title;Methodological Validity and Feasibility of the Nitric Oxide Clamp Technique for Nitric Oxide Research in Human Resistant Vessels |
| Author;
UEDA S
(Univ. Ryukyus School Of Medicine, Okinawa, Jpn)
WADA A
(Yokohama City Univ. School Of Medicine, Yokohama, Jpn)
UMEMURA S
(Yokohama City Univ. School Of Medicine, Yokohama, Jpn)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.5;PAGE.351-357(2004)
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| Figure&Table&Reference;FIG.4, REF.31 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Examination was made on a NO (nitric oxide) clamp method developed to estimate the role of nitric oxide (NO) in the human blood vessel more accurately in vivo. NG-methyl-L-arginine (L-NMMA) and glyceryltrinitrate (GTN) were administered to the healthy male intraarterially, and the blood flow in forearm division was measured by the plethysmography in the NO clamp method. The blood flow in forearm division lowered in 20 minutes after starting L-NMMA injection and it was recovered within 5 minutes by GTN injection, and it was fixed for 60 minutes. There was the reproducibility on the dose of GTN which was decided individually. Though the vasodilator response for ANP lowered by L-NMMA, it did not lower in the NO clamp method. Though the vasodilator response for acetylcholine lowered by L-NMMA, the degree of lowering was small in the NO clamp method. It was shown that the NO clamp method could evaluate the contribution of NO to flow response in forearm division for the vasodilator agent more accurately. |
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