Lack of Association between the Hepatocyte Growth Factor Receptor, c-met, and the Anti-Apoptotic Action of Bag-1 in Endothelial Cells
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Accession number;04A0428320
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| Title;Lack of Association between the Hepatocyte Growth Factor Receptor, c-met, and the Anti-Apoptotic Action of Bag-1 in Endothelial Cells |
| Author;
NAKAGAMI H
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
MORISHITA R
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
NISHIKAWA T
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
SHIMIZU H
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
IGUCHI S
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
MATSUMOTO K
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
NAKAMURA T
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
KANEDA Y
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
OGIHARA T
(Osaka Univ. Graduate School Of Medicine, Suita, Jpn)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.5;PAGE.359-365(2004)
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| Figure&Table&Reference;FIG.4, REF.31 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Anti-apoptotic action of Bag-1 in endothelial cells was examined. The endogenous expression of Bag-1 in human and cattle aorta endothelial cells was mainly recognized in the cytosol. The human HGF rose the avidity of Bag-1 and c-met. The human HGF stimulated tyrosine kinase phosphorylation, ERK phosphorylation, DNA synthesis, which was not subject to the over-expression of Bag-1 or C-terminal region deletion mutant. The apoptosis induced in TNF-alpha processing or under the non-blood serum condition lowered by the over-expression of Bag-1 or C-terminal region deletion mutant. The anti-apoptosis action of HGF was not risen by the Bag-1 over-expression. The Bag-1 under-expression in the endothelial cell showed the anti-apoptosis action, which indicated that this was not related to the HGF signal transmission. |
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