Long-term Clinical Remission in Response to Glucocorticoid Therapy in a Chihuahua with Granulomatous Meningoencephalitis
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Accession number;04A0543127
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| Title;Long-term Clinical Remission in Response to Glucocorticoid Therapy in a Chihuahua with Granulomatous Meningoencephalitis |
| Author;
KONTANI YUKO
(Hokkaido Univ., Graduate School of Veterrinary Medicine, JPN)
YAMATO OSAMU
(Hokkaido Univ., Graduate School of Veterrinary Medicine, JPN)
OCHIAI KENJI
(Hokkaido Univ., Graduate School of Veterrinary Medicine, JPN)
YAMASAKI MASAHIRO
(Hokkaido Univ., Graduate School of Veterrinary Medicine, JPN)
MAEDE YOSHIMITSU
(Hokkaido Univ., Graduate School of Veterrinary Medicine, JPN)
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Journal Title;Journal of the Japan Veterinary Medical Association
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Journal Code:Y0220A
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ISSN:0446-6454
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VOL.57;NO.7;PAGE.446-450(2004)
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| Figure&Table&Reference;FIG.5, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Glucocorticoid therapy resulted in long-term clinical remission in a 4-year-old female Chihuahua with granulomatous meningoencephalitis. A 2-week therapy regimen using dexamethasone improved such initial neurological symptoms as ataxia, tetraplegia, spasticity in the right side of body, leftward head-tilt, and nystagmus. Subsequent oral administration of prednisone (0.2-0.5 mg/kg every other day) sustained clinical remission for 2 and a half years. But severe motor dysfunction, seizures, occurred 2 years and 8 to 9 months after the start of therapy. Poor prognosis ultimately led to humane euthanasia. Pathological examination revealed reduction of the left cerebellar hemisphere accompanied by marked meningeal thickening. On the basis of histopathological features, the dog's condition was diagnosed as disseminated granulomatous meningoencephalitis. (author abst.) |
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