Histopathological Findings in Cytomegalovirus Retinitis
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Accession number;04A0557369
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| Title;Histopathological Findings in Cytomegalovirus Retinitis |
| Author;
KASHIWASE MITSUTOSHI
(Tokyo Medical Univ., JPN)
YAMAUCHI YASUYUKI
(Tokyo Medical Univ., JPN)
SATA TETSUTARO
(National Inst. Infectious Diseases, JPN)
NAGATA YOICHI
(Advanced Clinical Res. Center, Inst. Medical Sci., Univ. Tokyo, JPN)
USUI NORIO
(Tokyo Medical Univ., JPN)
MOCHIZUKI MANABU
(Tokyo Medical and Dental Univ., Graduate School, JPN)
FUJINO YUJIRO
(Tokyo Kosei-Nenkin Hosp.)
IWASAKI TAKUYA
(National Inst. Infectious Diseases, JPN)
SATO YUKO
(National Inst. Infectious Diseases, JPN)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.108;NO.7;PAGE.415-422(2004)
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| Figure&Table&Reference;FIG.7, TBL.4, REF.24 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: We examined eyeballs collected from autopsied acquired immunodeficiency syndrome patients with cytomegalovirus (CMV) retinitis, and analyzed the precise pathogenesis of CMV retinitis. Material and Methods: Eyeballs were fixed with 10% buffered formalin embedded in paraffin. CMV antigens were investigated by histopathological and immunohistochemical analyses. Histopathological findings were compared with funduscopic images. Results: CMV antigens remained in the necrotic area of the retina and many CMV immediate early antigens existed in intact parts of the inner retina showing almost intact structure, and around retinal vessels. Conclusions: The results suggest that CMV infects the inner retina first via the retinal vessels, although funduscopic examination may appear normal. It extends through the neuronal cells and glial cells horizontally and Mueller cells vertically. CMV severely damages the retinal structure. (author abst.) |
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