Short and Long Term Hypotensive Effect of Timolol-gel and Latanoprost Instillation in Normal-tension Glaucoma
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Accession number;04A0631303
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| Title;Short and Long Term Hypotensive Effect of Timolol-gel and Latanoprost Instillation in Normal-tension Glaucoma |
| Author;
HASHIMOTO TAKAKO
(Jichi Medical School, Dep. Medicine, JPN)
HARA TAKESHI
(Jichi Medical School, Dep. Medicine, JPN)
TAKAHASHI YASUKO
(Jichi Medical School, Dep. Medicine, JPN)
KUBOTA SHUNSUKE
(Jichi Medical School, Dep. Medicine, JPN)
KUBOTA MIYUKI
(Jichi Medical School, Dep. Medicine, JPN)
TSURU TADAHIKO
(Jichi Medical School, Dep. Medicine, JPN)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.108;NO.8;PAGE.477-481(2004)
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| Figure&Table&Reference;FIG.1, TBL.4, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To confirm the predictive value of the results of a 4-week trial of latanoprost alone, timolol-gel alone, or a combination of the two in normal-tension glaucoma(NTG) patients, when compared with the hypotensive response after a 6-month trial using the same combination of eye drops for the same patients. Methods: One eye each of 45 NTG patients was used in a prospective 4-week trial of latanoprost alone, timolol-gel alone, or a combination of the two. Patients continued using the eye drops for 6 months, according to the results of the trial. The correlation of the results of the 6-month use and the baseline data, and the baseline data and the results of the 4-week trial were evaluated by the paired-t test. Results: The intraocular pressure (IOP)s of patients using timolol-gel alone were 13.9 mmHg at the base line, 9.7 mmHg after the trial, and 12.0 mmHg after 6-month use (baseline, trial: p<0.05). IOPs when using latanoprost alone were 15.3 mmHg at baseline, 11.7 mmHg after the trial, and 11.5 mmHg after 6-month use(baseline: p<0.05, trial p=0.33). IOPs using timolol-gel and latanoprost in combination were 14.8 mmHg at baseline, 11.4 mmHg after the trial, and 12.0 mmHg after 6-month use (baseline: p<0.05, trial: p=0.14). Conclusion: The result of the 4-weeks trial of latanoprost alone or in combination with timolol-gel can be indicative of the IOP after 6-month use. (author abst.) |
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