Lipoprotein Lipase Gene Polymorphisms and Blood Pressure Levels in the Northern Chinese Han Population
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Accession number;04A0514403
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| Title;Lipoprotein Lipase Gene Polymorphisms and Blood Pressure Levels in the Northern Chinese Han Population |
| Author;
LI B
(Inst. Biophysics, Chinese Acad. Sci., Beijing, Chn)
GE D
(Chinese Acad. Medical Sci., Beijing, Chn)
WANG Y
(Inst. Biophysics, Chinese Acad. Sci., Beijing, Chn)
ZHAO W
(Chinese Acad. Medical Sci., Beijing, Chn)
ZHOU X
(Chinese Acad. Medical Sci., Beijing, Chn)
GU D
(Chinese Acad. Medical Sci., Beijing, Chn)
CHEN R
(Inst. Biophysics, Chinese Acad. Sci., Beijing, Chn)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.6;PAGE.373-378(2004)
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| Figure&Table&Reference;TBL.4, REF.34 |
| Pub. Country;Japan |
| Language;English |
| Abstract;In the previous study on the Chinese hypertensive families, it was indicated that the LPL gene was a logical candidate gene for involvement in the underlying cause of essential hypertension (EH). In the present study, 22 sequence variants were identified by directly sequencing 10 exons and flanking regions of the LPL gene. The occurrence of 3 of, IVS4-214C>T, 7754C>A and S447X, was examined in 501 normotensive (NT) subjects and 497 EH subjects. In males, the frequencies of the genotypes of each of the 3 variants did not differ between the NT and EH groups. In females, the distribution of the 7754C>A genotype and the frequency of the A allele of 7754C>A differed significantly between the NT and EH groups. Halo type analysis revealed that T-A-C and T-C-G halo type were statistically more frequent in the NT group than in the EH group in both females and males. Individual single nucleotide polymorphism (SNP) analysis did not provide substantial evidence of an association between polymorphisms in the LPL gene and hypertension statues and/or blood pressure levels in the cohort. |
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