Comparison between Cilnidipine and Amlodipine Besilate with Respect to Proteinuria in Hypertensive Patients with Renal Diseases
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Accession number;04A0514404
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| Title;Comparison between Cilnidipine and Amlodipine Besilate with Respect to Proteinuria in Hypertensive Patients with Renal Diseases |
| Author;
KOJIMA S
(National Hospital Organization Shizuoka Medical Center, Shizuoka, Jpn)
SHIDA M
(National Hospital Organization Shizuoka Medical Center, Shizuoka, Jpn)
YOKOYAMA H
(National Hospital Organization Shizuoka Medical Center, Shizuoka, Jpn)
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Journal Title;Hypertens Res
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Journal Code:Y0303A
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ISSN:0916-9636
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VOL.27;NO.6;PAGE.379-385(2004)
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| Figure&Table&Reference;FIG.3, TBL.3, REF.31 |
| Pub. Country;Japan |
| Language;English |
| Abstract;For the investigation of the titled items, 28 cases with the titled disease who had been maintained on calcium channel blockers (CCBs) for more than 3 months were randomly assigned to a group receiving amlodipine (A) (14 cases) or cilnidipine (C) (14 cases). CCBs were increased in dosage or other drugs were added until blood pressure decreased below 140/90mmHg. No inhibitors of the renin-angiotensin system were added or changed in dosage. The concentration of urine protein, urine albumin, serum and urine creatinine (Cr), and serum .BETA.2-microglobulin were determined before the examination and 6 and 12 months after the randomization. Proteinuria was increased in the group A by 87% and in the group C by 4%. A significant intergroup difference was observed. The mean blood pressure remained in the 96-99mmHg range during the test, and no difference was observed between the two groups. The group C showed an increase in serum Cr levels. An inverse correlation existed between the changes in Cr and proteinuria. It was indicated that C resulted in a greater suppression of the increase in proteinuria and greater reduction in glomerular filtration rate than A. |
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