Immunolocalization of Lymphocyte Subsets in the Testis and Epididymis of Roosters
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Accession number;04A0805722
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| Title;Immunolocalization of Lymphocyte Subsets in the Testis and Epididymis of Roosters |
| Author;
YOSHIMURA Y
(Graduate School Of Biosphere Sci., Higashi-hiroshima, Jpn)
TAMURA Y
(Graduate School Of Biosphere Sci., Higashi-hiroshima, Jpn)
LIANG J X
(Graduate School Of Biosphere Sci., Higashi-hiroshima, Jpn)
OKAMOTO T
(Graduate School Of Biosphere Sci., Higashi-hiroshima, Jpn)
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Journal Title;J Poult Sci
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Journal Code:G0008B
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ISSN:1346-7395
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VOL.41;NO.4;PAGE.315-321(2004)
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| Figure&Table&Reference;FIG.2, REF.26 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The goal of this study was to localize the T cell subsets and B cells in the testis and epididymis of roosters. Frozen sections of testis and epididymis were immunostained for CD4, CD8 and Bu1, which are the specific surface antigens of helper/inducer T cells, cytotoxic/suppressor T cells and B cells, respectively. Both CD4+ and CD8+ T cells were located in the interstitial tissues of testis. In the epididymis many CD4+ and CD 8+ T cells were localized in the subepithelial layer (subepithelial stroma and fibromuscular layer) of efferent ductules and epididymal duct. Both T cell subsets were also distributed in the epididymal interstitial tissues. Some CD4+ and CD8+ T cells were localized in the lumen of efferent ductules and epididymal duct. No significant difference was observed in the frequencies between CD4+ and CD8+ T cells in each tissue. The Bu1+ B cells were observed in the testicular and epididymal interstitial tissues at a low frequency. These results suggest that in the testis and epididymis immunodefense system to pathogens are formed primarily by T cells. Cell-mediated immunoresponse to sperm may occur in the ductules of the epididymis, whereas induction of auto-antibodies to sperm may be prevented because of a low population of B cells and possibly by the regulation of CD8+ T cells. (author abst.) |
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