Topical Reactions Against Intracutaneous Injection of Three Hyaluronan Products, Artz, Synvisc and Durolane in Guinea Pigs
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Accession number;04A0864558
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| Title;Topical Reactions Against Intracutaneous Injection of Three Hyaluronan Products, Artz, Synvisc and Durolane in Guinea Pigs |
| Author;
OHARA N
(Hatano Res. Inst.)
MATSUOKA C
(Hatano Res. Inst.)
NAGATA T
(Hatano Res. Inst.)
KANAZAWA Y
(Hatano Res. Inst.)
INADA H
(Hatano Res. Inst.)
HORIUCHI S
(Hatano Res. Inst.)
SAEGUSA K
(Hatano Res. Inst.)
ONO H
(Hatano Res. Inst.)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.32;NO.10;PAGE.663-677(2004)
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| Figure&Table&Reference;FIG.4, TBL.6, REF.29 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The aim of the present study was to compare skin reactions against three hyaluronan (HA) products: Artz, a purified natural HA obtained from chicken comb; Synvisc, a chemically cross-linked chicken comb HA; and Durolane, a biosynthetic HA with molecular cross-linking. These HA products were intracutaneously injected to the back of guinea pigs and the animals were observed for skin reactions for 28 days. Both Synvisc and Durolane resided longer in the tissue than Artz. However, the cross-linking HA products caused erythema, and moreover, Synvisc exhibited delayed skin reaction. In passive cutaneous anaphylaxis test only the sera from Synvisc-treated animals showed a significant titer to Synvisc, whereas sera from the animals treated with Durolane or Artz had no effects. Therefore it is possible that some of cross-linked HA products show antigenicity which might be due to contaminated antigenic and/or antigen-inducing substances, though such products have an advantage of longer residence time. In contrast natural molecule HA products appear far less inflammatogenic, while its residence time is somewhat shorter. (author abst.) |
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