Ameliorative Effects of Sarpogrelate Alone or Combined with Lipo PGE1 on Decreased Dermal Blood Flow in Rat Hind Paw Ischemia Model
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Accession number;05A0015057
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| Title;Ameliorative Effects of Sarpogrelate Alone or Combined with Lipo PGE1 on Decreased Dermal Blood Flow in Rat Hind Paw Ischemia Model |
| Author;
AKIRA TOSHIAKI
(Mitsubishi Pharma Corp., JPN)
NAKAGAWA HARUTO
(Mitsubishi Pharma Corp., JPN)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.32;NO.11;PAGE.781-786(2004)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Objectives: The present study was performed employing a lower extremity ischemia model for a pharmacological basis in treating peripheral circulatory disturbances with sarpogrelate alone or concomitant with Lipo PGE1, prostaglandin E1 encapsulated into lipid microsphere. Methods: A critical limb ischemia was given to the lower extremity of the rat with a preceding unilateral occlusion of the common femoral artery by intraarterial administration of the suspension of platelet-rich plasma following ADP-induced platelet aggregation. The test drugs of anti-platelet, sarpogrelate, Lipo PGE1, beraprost, cilostazol were each administered in their favorable ways and doses, and evaluated their improved effects against the reduced dermal blood flow in the hind paw. Results: Sarpogrelate (30mg/kg) was highly effective to the limb ischemia, presumably on behalf of its utilization of collateral perfusion. Other agents were also beneficial to the peripheral ischemia at various extents of efficacies. In specialty, these vasodilative prostanoids improved the ischemic status of the rat at low doses of 3.MU.g/kg. Furthermore, concomitant administration of sarpogrelate with Lipo PGE1 was overdriven the effect of each single application. Conclusions: Based on the present results given by enhanced availability of collateral perfusion with sarpogrelate, especially in the combination of Lipo PGE1, the pharmacological usefulness of the anti-platelets agents was shown in a limb ischemia model upon their synergistic effects. (author abst.) |
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