The Inhibitory Action of Indisetron Hydrochloride, a 5-HT3 Receptor Antagonist, Against the Anticancer Drug-induced Emesis in the Dog, Ferret and Suncus
|
Accession number;05A0015059
|
| Title;The Inhibitory Action of Indisetron Hydrochloride, a 5-HT3 Receptor Antagonist, Against the Anticancer Drug-induced Emesis in the Dog, Ferret and Suncus |
| Author;
TANIGUCHI SUGURE
(Nisshinkyorinseiyaku)
HAGIHARA KOICHIRO
(Nisshinkyorinseiyaku)
HAMADA TAMIKO
(Nisshinkyorinseiyaku)
MINAMI MASARU
(Health Sci. Univ. Hokkaido)
ENDO TOORU
(Health Sci. Univ. Hokkaido)
TSUCHIYAMA MICHIO
(Environmental Biological Life Sci. Res. Center Inc., JPN)
|
Journal Title;Japanese Pharmacology & Therapeutics
|
Journal Code:Z0947A
|
ISSN:0386-3603
|
|
VOL.32;NO.11;PAGE.799-806(2004)
|
| Figure&Table&Reference;TBL.5, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The inhibitory action of novel 5-HT3 receptor antagonist indisetron hydrochloride (indisetron) against the anticancer drug-induced emesis was examined in the various animals. Cisplatin, the anticancer drug, induced acute emesis in the dog (the dose of cisplatin was 3mg/kg), ferret (10mg/kg) and suncus (50mg/kg). Cisplatin at the low dose (5mg/kg) induced acute (0-24 hour) and delayed (24-72 hour) emesis in the ferret. The other anticancer drug, cyclophosphamide (200mg/kg) also induced acute emesis in the ferret. The inhibitory action of indisetron was examined in all these emesis models and compared with granisetron or ondansetron in some models. Indisetron (1mg/kg p.o.) inhibited the cisplatin-induced acute emesis in the dog, ferret and suncus. Granisetron inhibited the emesis in the dog with 0.3mg/kg p.o. but in the suncus with 10mg/kg p.o. Indisetron (1mg/kg s.c. twice per day) also suppressed the low dose cisplatin-induced emesis in the ferret for acute and delayed phase. Ondansetron (1mg/kg s.c. twice per day) did not suppress the cisplatin-induced emesis in the ferret for delayed phase but for acute phase. Indisetron (1mg/kg p.o.) inhibited the cyclophosphamide-induced emesis in the ferret. From these results, we found that indisetron ameliorate the anticancer drug-induced emesis at several animals in the same dosage. Indisetron may be a useful drug that prevent the anticancer drug-induced emesis in the chemotherapy. (author abst.) |
|
|
|
Related Articles;
|
|
