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Accession number;05A0015579
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| Title;The role of innate immunity infection & development |
| Author;
SHIMOJO NAOKI
(Graduate School of Medicine, Chiba Univ., JPN)
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Journal Title;Allergy in Practice
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Journal Code:Z0246B
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ISSN:0285-6379
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VOL.;NO.327;PAGE.33-37(2005)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Natural immunity is the defense mechanism which nonspecially removees the antigen of pathogenic microbe by defense mechanism of the host. A T cell shoulders the important role in the natural immunity in upper respiratory tract infection. Especially, the .GAMMA..DELTA.T cell is important in a RS virus (RSV) infection as a productive cell of interferon .GAMMA.(IFN-.GAMMA.), and the IFN-.GAMMA. production quantity may be related to the repetitive stridor. Though Tolllikereceptor(TLR)4 is receptor of the F protein of RSV, it is reported that the TLR4 gene polymorphism is related to the seriousness of the RSV bronchiolitis in foreign countries. And, it is known that TLR3 regulates the reactivity to the rhino virus. Therefore, .GAMMA..DELTA.T cell and individual specificity of the function of TLR may be concerned in asthma crisis and deterioration of the viral infection. |
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