Two New Sesquiterpene Lactones from Ixeris chinensis
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Accession number;05A0008510
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| Title;Two New Sesquiterpene Lactones from Ixeris chinensis |
| Author;
KHALIL A T
(National Sun Yat-sen Univ., Kaohsiung, Twn)
SHEN Y-C
(National Sun Yat-sen Univ., Kaohsiung, Twn)
GUH J-H
(National Taiwan Univ., Taipei, Twn)
CHENG S-Y
(National Sun Yat-sen Univ., Kaohsiung, Twn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.53;NO.1;PAGE.15-17(2005)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.22 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Phytochemical investigation of Ixeris chinensis NAKAI (Asteraceae) has resulted in the isolation of a new guaianolide-type sesquiterpene lactone, ixerochinolide (1) as well as the related glucoside, ixerochinoside (2). In addition, the known guaianolides, 8.BETA.-hydroxy-3-oxo-guaia-4(15),10(14),11(13)-trien-1.ALPHA.,5.ALPHA.,6.BETA.,7.ALPHA.H-12,6-olide (8.BETA.-hydroxydehydrozaluzanin), 8.BETA.,15-dihydroxy-2-oxo-guaia-1(10),3,11(13)-trien-5.ALPHA.,6.BETA.,7.ALPHA.H-12,6-olide (lactucin), 3.BETA.,8.ALPHA.,10.ALPHA.-trihydroxy-guaia-4(15),11(13)-dien-1.ALPHA.,5.ALPHA.,6.BETA.,7.ALPHA.H-12,6-olide (10.ALPHA.-hydroxy-10,14-dihydro-desacylcynaropicrin) and 3.BETA.-D-glucopyranosyloxy-8.BETA.-(p-hydroxyphenylacetyloxy)-guaia-4(15),10(14),11(13)-trien-1.ALPHA.,5.ALPHA.,6.BETA.,7.ALPHA.H-12,6-olide (8-epicrepioside) were identified. The structures were determined on the basis of spectral analyses, especially 1- and 2D NMR. Compound 1 exhibited significant cytotoxicity against human PC-3 tumor cells. (author abst.) |
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