Preparation of 2-Pyridone-Containing Tricyclic Alkaloid Derivatives as Potential Inhibitors of Tumor Cell Proliferation by Regioselective Intramolecular N- and C-Acylation of 2-Pyridone
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Accession number;05A0008522
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| Title;Preparation of 2-Pyridone-Containing Tricyclic Alkaloid Derivatives as Potential Inhibitors of Tumor Cell Proliferation by Regioselective Intramolecular N- and C-Acylation of 2-Pyridone |
| Author;
WANG S
(Nanjing Univ., Nanjing, Chn)
CAO L
(Nanjing Univ., Nanjing, Chn)
SHI H
(Nanjing Univ., Nanjing, Chn)
DONG Y
(Nanjing Univ., Nanjing, Chn)
SUN J
(Nanjing Univ., Nanjing, Chn)
HU Y
(Tsinghua Univ., Beijing, Chn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.53;NO.1;PAGE.67-71(2005)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.49 |
| Pub. Country;Japan |
| Language;English |
| Abstract;A novel and practical preparation of 2-pyridone-containing tricyclic alkaloid derivatives was developed. By regioselective intramolecular N- and C-acylation of 2-(4-aryl-2-pyridon-6-yl)benzoic acid, a pair of structural isomers 2-aryl pyrido[2,1-a]isoindole-4,6-diones and 4-aryl 1-methyl-1H-indeno[1,2-b]-pyridine-2,5-diones, as potential inhibitors of tumor cell proliferation, were prepared respectively. (author abst.) |
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