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Accession number;05A0008529
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| Title;A Convenient Synthesis of Immunosuppressive Agent FTY720 Using the Petasis Reaction |
| Author;
SUGIYAMA S
(Meiji Pharmaceutical Univ., Tokyo, Jpn)
ARAI S
(Meiji Pharmaceutical Univ., Tokyo, Jpn)
KIRIYAMA M
(Meiji Pharmaceutical Univ., Tokyo, Jpn)
ISHII K
(Meiji Pharmaceutical Univ., Tokyo, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.53;NO.1;PAGE.100-102(2005)
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| Figure&Table&Reference;FIG.1, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;A convenient synthesis of immunosuppressive agent FTY720 (1) using the Petasis reaction was developed. 4-Octylbenzaldehyde (9) was converted into 1-ethenyl-4-octylbenzene (11) by two-step synthesis. Hydroboration of 11 using catecholborane and hydrolysis gave (E)-2-(4-octylphenyl)vinylboronic acid (4). The Petasis reaction of 4, dihydroxyacetone (3), and benzylamine following catalytic hydrogenation afforded FTY720 (1). (author abst.) |
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