New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense
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Accession number;05A0008533
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| Title;New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense |
| Author;
DAT N T
(Chungnam National Univ., Deajeon, Kor)
CAI X F
(Chungnam National Univ., Deajeon, Kor)
SHEN Q
(Chungnam National Univ., Deajeon, Kor)
LEE I S
(Chungnam National Univ., Deajeon, Kor)
KIM Y H
(Chungnam National Univ., Deajeon, Kor)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.53;NO.1;PAGE.114-117(2005)
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| Figure&Table&Reference;FIG.2, TBL.3, REF.28 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Two new compounds were isolated from the stem and twigs of Ribes fasciculatum var. chinense and their structures were identified to be threo-(7S,8R)-1-(4-hydroxyphenyl)-2-[4-(E)-propenylphenoxy]-propan-1-ol (1), and 5,4'-dihydroxy-7-methoxyflavone-3-O-[.ALPHA.-L-rhamnopyranosyl(1.RAR.3)-O-.ALPHA.-L-rhamnopyranosyl(1.RAR.6)-O-.BETA.-D-glucopyranoside] (2). With nine other known components, they were tested on inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. Compound 1 showed a potent inhibitory activity (IC50=15.6 .MU.M), while compounds 4, 5 and 9 showed moderate inhibitory activity (IC50 22.4, 24.5 and 25.7 .MU.M, respectively). (author abst.) |
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