Neolignans from Piper futokadsura and Their Inhibition of Nitric Oxide Production
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Accession number;05A0008535
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| Title;Neolignans from Piper futokadsura and Their Inhibition of Nitric Oxide Production |
| Author;
KONISHI T
(Kyoto Pharmaceutical Univ., Kyoto, Jpn)
KONOSHIMA T
(Chiba Inst. Of Sci., Chiba, Jpn)
DAIKONYA A
(Nihon Univ., Chiba, Jpn)
KITANAKA S
(Nihon Univ., Chiba, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.53;NO.1;PAGE.121-124(2005)
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| Figure&Table&Reference;FIG.1, TBL.3, REF.27 |
| Pub. Country;Japan |
| Language;English |
| Abstract;From a MeOH extract of the aerial part of Piper futokadsura, the tetrahydrofuran lignans, futokadsurin A [(7S,8S,7'S,8'R)-3,4,3'-trimethoxy-4'-hydroxy-7,7'-epoxylignan], futokadsurin B [(7R,8R,7'R,8'S)-3,4-dimethoxy-3',4'-methylenedioxy-7,7'-epoxylignan], and futokadsurin C [(7R,8R,7'S,8'S)-3,4-methylenedioxy-3',4'-dimethoxy-7,7'-epoxylignan] were isolated, together with nine known neolignans. In addition, L-tryptophan, pellitorine, phytol, elemicin, and 1,2,4-trimethoxyphenyl-5-aldehyde were isolated. The structures of the new compounds were elucidated using spectroscopic methods. These lignans inhibited nitric oxide production by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide and interferon-.GAMMA.. (author abst.) |
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