Stereoselective Synthesis of (E)- and (Z)-.BETA.-Bromostyrene Containing Trifluoromethyldiazirine for Photoaffinity Labeling
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Accession number;05A0008541
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| Title;Stereoselective Synthesis of (E)- and (Z)-.BETA.-Bromostyrene Containing Trifluoromethyldiazirine for Photoaffinity Labeling |
| Author;
HASHIMOTO M
(Obihiro Univ. Agriculture And Veterinary Medicine, Hokkaido, Jpn)
KOMANO T
(Obihiro Univ. Agriculture And Veterinary Medicine, Hokkaido, Jpn)
NABETA K
(Obihiro Univ. Agriculture And Veterinary Medicine, Hokkaido, Jpn)
HATANAKA Y
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.53;NO.1;PAGE.140-142(2005)
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| Figure&Table&Reference;FIG.1, REF.20 |
| Pub. Country;Japan |
| Language;English |
| Abstract;A convenient procedure for the synthesis of (E)- and (Z)-.BETA.-bromostyrene containing trifluoromethyldiazirine is described, which involves the stereoselective reduction of the corresponding trifluoromethyldiazirinyl .BETA.,.BETA.-dibromostyrene without damaging the photophor. The synthetic route easily introduced deuterium, which can be utilized for the detection of a photolabeled component by MS spectrometry, after construction of a trifluoromethyldiazirinyl skeleton. (author abst.) |
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