Urtra Fast Laser Activated Photodynamic Therapy for Neovascularization
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Accession number;05A0094905
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| Title;Urtra Fast Laser Activated Photodynamic Therapy for Neovascularization |
| Author;
AWAZU KUNIO
(Osaka Univ., Graduate School of Engineering, JPN)
SUZUKI SACHIKO
(Osaka Univ., Graduate School of Engineering, JPN)
SAWA MIKI
(Osaka Univ., Graduate School of Medicine, JPN)
OJI MASATO
(Osaka Univ., Graduate School of Medicine, JPN)
TANO YASUO
(Osaka Univ., Graduate School of Medicine, JPN)
IWAMOTO YUMIKO
(Kinki Univ., Graduate School of Sci. and Technol., JPN)
HASHINI YUICHI
(Kinki Univ., Graduate School of Sci. and Technol., JPN)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.32;NO.Suppl.2;PAGE.S.167-S.171(2004)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;ICG has been widely used as a sensitive tracer of hepatic function. As a novel application of ICG, we estimated it as a photosensitizer for Photodynamic Therapy (PDT). In this research, ICG in tissues was excited by ultra short pulsed laser, femto second laser, for ICG-PDT. The ICG-PDT of age-related macular degenerations by the corneal neovascularization (in vivo) was examined using albino rabbits. As results, The femto second laser having 800 nm wavelength at 40J/cm2 did not give the thermal damage to a normal tissue without ICG because of the thermal confinement interaction. Laser exposure 30 seconds after ICG injection was effective for occlusion of new vessels. Therefore, ICG can be used as a photosensitizer with less photosensitivity in visible region. (author abst.) |
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