Rapid Enantioseparation of 1-Aminoindan by Microchip Electrophoresis with Linear-Imaging UV Detection
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Accession number;05A0095069
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| Title;Rapid Enantioseparation of 1-Aminoindan by Microchip Electrophoresis with Linear-Imaging UV Detection |
| Author;
KITAGAWA F
(Kyoto Univ., Kyoto, Jpn)
AIZAWA S
(Kyoto Univ., Kyoto, Jpn)
OTSUKA K
(Kyoto Univ., Kyoto, Jpn)
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Journal Title;Anal Sci
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Journal Code:G0673B
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ISSN:0910-6340
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VOL.21;NO.1;PAGE.61-65(2005)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.54 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Chiral separations of 1-aminoindan (AI) by cyclodextrin electrokinetic chromatography (CDEKC) were investigated on microfluidic quartz chips. By using a microchip electrophoresis (MCE) instrument equipped with a linear-imaging UV detector, the separation process of the enantiomeric compounds was observed. When sulfated .BETA.-cyclodextrin was employed as a chiral selector, the baseline separation of AI could be achieved within 1 min with a high repeatability. The relative standard deviation of the migration time was less than 6%. The fastest separation was achieved in 14 s, utilizing a separation length of only 6.1 mm. These results show that the MCE analysis employing a linear imaging UV detector has a significant potential for fast chiral analysis. (author abst.) |
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