Science Links Japan | Clinical Efficacy of Loxoprofen Sodium for Noeturia on Patients with Neurogenic Bladder: A Non-randomized Study of Loxoprofen 60mg Once Daily before Sleeping.

Clinical Efficacy of Loxoprofen Sodium for Noeturia on Patients with Neurogenic Bladder: A Non-randomized Study of Loxoprofen 60mg Once Daily before Sleeping.

Accession number;05A0100732

Title;Clinical Efficacy of Loxoprofen Sodium for Noeturia on Patients with Neurogenic Bladder: A Non-randomized Study of Loxoprofen 60mg Once Daily before Sleeping.

Author; ARAKI TOORU (Arakijinhinyokikakurinikku) YOKOYAMA TERUHIKO (Graduate School of Medicine and Dentistry, Okayama Univ., JPN)

Journal Title;Journal of Clinical Therapeutics & Medicines

Journal Code:Y0906A

ISSN:0910-8211

VOL.21;NO.1;PAGE.89-95(2005)

Figure&Table&Reference;FIG.1, TBL.4, REF.22

Pub. Country;Japan

Language;Japanese

Abstract;We have already reported a good efficacy of loxoprofen sodium, which is one of the most common nonsteroidal anti-inflammatory drugs in Japan, for refractory nocturia in patients with benign prostatic hyperplasia (BPH). In this study, the efficacy of loxoprofen sodium for nocturia in patients with neurogenic bladder (NB) was explored. Patients and Methods A total of 31 patients aged 59-87 years were enrolled in this study. These patients had already received .ALPHA.1blockers, anticholinergic drugs, tricyclic antidepressants and/or hypnotics, either alone or in combination in addition to usual NB therapy, however they still complained of 2 or more episodes of nocturia. Each patient took a single 60mg tablet of loxoprofen prior to sleeping at night for 14 days in addition to their NB treatments. The effects were assessed by questionnaire before, during and after treatment as excellent (nocturia disappeared or decreased by 2 or more voids/night), improved (nocturia decreased by 1 void/night), unchanged, and worsened (nocturia increased). Results: Nocturia improved or disappeared in 80.6 % of patients. Excellent, improved, unchanged, and worsened were obtained 41.9%, 38.7%, 16.1 %, and 3.2% of patients, respectively. The effects were significantly better in patients whose baseline frequency of nocturia was .GEQ. voids/night than in those with lesser baseline frequency (excellent rate :15.4% vs. 61.1 %. p = 0.025). In addition, the effects continued in some patients after the termination of the treatment. One patient discontinued due to an adverse event of mild gastric discomfort. Conclusions : Loxoprofen can be effective and useful treatment for refractory nocturia in patients with NB, as well as in patients with BPH. (author abst.)

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