A Dammarane Glycoside Derived from Ginsenoside Rb3
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Accession number;05A0106836
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| Title;A Dammarane Glycoside Derived from Ginsenoside Rb3 |
| Author;
HE K
(Dalian Inst. Of Chemical Physics, Chinese Acad. Of Sci., Dalian, Chn)
LIU Y
(Dalian Inst. Of Chemical Physics, Chinese Acad. Of Sci., Dalian, Chn)
YANG Y
(Dalian Inst. Of Chemical Physics, Chinese Acad. Of Sci., Dalian, Chn)
LI P
(Dalian Inst. Of Chemical Physics, Chinese Acad. Of Sci., Dalian, Chn)
YANG L
(Dalian Inst. Of Chemical Physics, Chinese Acad. Of Sci., Dalian, Chn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.53;NO.2;PAGE.177-179(2005)
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| Figure&Table&Reference;TBL.3, REF.15 |
| Pub. Country;Japan |
| Language;English |
| Abstract;A dammarane glycoside, designated compound Mx (C-Mx), was isolated from the hydrolysate of 20(S)-protopanaxadiol type ginsenosides containing G-Rb3 from Panax notoginseng leaves with crude snailase. Its chemical structure was elucidated to be 20-O-.BETA.-D-xylopyranosyl(1.RAR.6)-.BETA.-D-glucopyranosyl-20(S)-protopanaxadiol on the basis of spectral analysis. Its cytotoxicity against breast cancer cell line MCF-7 and effects on the sensitivity to doxocubicin of doxocubicin-resistant MCF-7 cells were also investigated. The new compound showed moderate cytotoxicity and partial reversal of doxocubicin resistance. (author abst.) |
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