Pancreatic Endocrine Function and Chronic Diabetic Complications Following Simultaneous Pancreas-Kidney Transplantation in Japan
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Accession number;05A0184949
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| Title;Pancreatic Endocrine Function and Chronic Diabetic Complications Following Simultaneous Pancreas-Kidney Transplantation in Japan |
| Author;
IWASE MASANORI
(Kyushu Univ., Graduate School, JPN)
SUGITANI ATSUSHI
(Kyudai Daigakuin Rinshoshuyogekagaku)
MOTOYAMA KENTARO
(Kyudai Daigakuin Rinshoshuyogekagaku)
YAMAMOTO HIROFUMI
(Kyudai Daigakuin Rinshoshuyogekagaku)
OTA MORIHITO
(Kyudai Daigakuin Rinshoshuyogekagaku)
YOSHIDA JUN'ICHI
(Kyudai Daigakuin Rinshoshuyogekagaku)
EGAMI TAKUYA
(Kyudai Daigakuin Rinshoshuyogekagaku)
HIRAKATA HIDEKI
(Kyushu Univ., Graduate School, JPN)
IIDA MITSUO
(Kyushu Univ., Graduate School, JPN)
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Journal Title;Journal of the Japan Diabetic Society
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Journal Code:Z0279B
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ISSN:0021-437X
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VOL.48;NO.1;PAGE.33-42(2005)
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| Figure&Table&Reference;FIG.2, TBL.5, REF.39 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Although simultaneous pancreas-kidney transplantation (SPK) is the established treatment for type 1 diabetic patients with end-stage renal failure, no studies have, to our knowledge, reported on chronic SPK patients after Japan's transplantation law was passed. We studied insulin secretion from pancreatic grafts and the effects of SPK on chronic diabetic complications in 4 patients with SPK conducted at least 1 year earlier. Insulin secretion in intravenous glucose tolerance tests decreased from 1 month after SPK in all 4, whereas 75 g oral glucose tolerance tests showed all but 1 patient (case 2), who had discontinued immunosuppresants due to noncompliance, to be normal. Two patients developed hypoglycemia 2 hours after glucose loading. Insulin secretion in glucagon load tests was low in case 2 and the patient donated from a non-beating heart donor (case 3). .ALPHA.-glucosidase inhibitor was administered in case 3 due to postprandial hyperglycemia (161 mg/dl). Glycemic control was excellent in all patients. After SPK, diabetic retinopathy remained unchanged, whereas autonomic neuropathy assessed by heart rate variability and the Schellong test was significantly improved (p<0.05). Ankle brachial blood pressure index and heart-carotid pulse wave velocity tended to improve. Although insulin secretion varied among the 4, blood glucose was well controlled and beneficial effects of SPK on chronic diabetic complications were observed. Despite the limited number of donors, with most donors marginal in Japan, our results appear to not be inferior those reported elsewhere. (author abst.) |
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