Antihypertensive Effects of Candesartan Cilexetil, Angiotensin II Receptor Blocker, on Ambulatory Blood Pressure
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Accession number;05A0194379
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| Title;Antihypertensive Effects of Candesartan Cilexetil, Angiotensin II Receptor Blocker, on Ambulatory Blood Pressure |
| Author;
SHIMADA KAZUYUKI
(Jichi Medical School, Dep. Medicine, JPN)
KARIO KAZUOMI
(Jichi Medical School, Dep. Medicine, JPN)
EGUCHI KAZUO
(Jichi Medical School, Dep. Medicine, JPN)
HOSHIDE SATOSHI
(Jichi Medical School, Dep. Medicine, JPN)
HOSHIDE YOKO
(Jichi Medical School, Dep. Medicine, JPN)
ISHIKAWA SHIZUKIYO
(School of Medicine, Jichi Medical School, JPN)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.21;NO.2;PAGE.177-186(2005)
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| Figure&Table&Reference;FIG.4, TBL.4, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We have performed an open-study in 43 essential hypertensives to investigate the antihypertensive efficacy and duration of Candesartan Cilexetil monotherapy on ambulatory blood pressure. Twenty-four-hours ambulatory BP (24hr BP) monitorings have been assessed twice at baseline and twice at the end of treatment. The decrease of 24hrBP, awaking-time BP, sleeping-time BP and early morning BP were 10.6mmHg/5.9mmHg, 11.7mmHg/6.6mmHg, 8.8mmHg/4.8mmHg and 11.2mmHg/7.6mmHg respectively (p .LEQ. 0.0001). On the other hand, pulse rates were not influenced except that of early morning. Candesartan showed also a good tolerability in safety. Candesartan monotherapy produced a smooth antihypertensive effect throughout the dose interval of 24 hr. (author abst.) |
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