Serum Levels of Interleukin-10 on Admission as a Prognosis Predictor of Human Fulminant Myocarditis
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Accession number;05A0202008
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| Title;Serum Levels of Interleukin-10 on Admission as a Prognosis Predictor of Human Fulminant Myocarditis |
| Author;
NISHII MOTOTSUGU
(Kitasato Univ., Sch. of Med.)
INOMATA TAKAYUKI
(Kitasato Univ., Sch. of Med.)
TAKEHANA HITOSHI
(Kitasato Univ., Sch. of Med.)
TAKEUCHI ICHIRO
(Kitasato Univ., Sch. of Med.)
NAKANO HIRONARI
(Kitasato Univ., Sch. of Med.)
KOITABASHI TOSHIMI
(Kitasato Univ., Sch. of Med.)
NAKAHATA JUN'ICHI
(Kitasato Univ., Sch. of Med.)
AOYAMA NAOYOSHI
(Kitasato Univ., Sch. of Med.)
IZUMI TOORU
(Kitasato Univ., Sch. of Med.)
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Journal Title;J Cardiol
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Journal Code:Y0264A
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ISSN:0914-5087
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VOL.45;NO.2;PAGE.82-84(2005)
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| Figure&Table&Reference;FIG.1, TBL.2 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Objectives. We assessed the significance of serum cytokine levels in patients with fulminant myocarditis. Background. Although many investigations have demonstrated the crucial role of cytokines on the development of myocarditis, it remains uncertain whether serum levels of cytokines are predictours of the prognosis of human myocarditis, especially concerning cardiogenic shock requiring mechanical circulatory support system (MCSS). Methods. We studied 22 consecutive patients with fulminant myocarditis and compared them with 15 patients with acute myocardial infarction requiring MCSS. The patients with myocarditis were classified into three groups: 8 patients with cardiogenic shock requiring MCSS on admission (Group 1), 6 patients who unexpectedly lapsed into cardiogenic shock requiring MCSS more than 2 days after catecholamine had been started (Group 2), and 8 patients without MCSS (Group 3). Furthermore, 14 patients with myocarditis requiring MCSS were divided into a fatal (n=5) and a survival group (n=9). Biochemical markers including serum cytokine levels and hemodynamic variables on admission were analyzed. Results. Serum levels of interleukin (IL)-10 and tumor necrosis factor-.ALPHA., but not other cytokines, were significantly higher in myocarditis than in acute myocardial infarction. Only serum levels of IL-10 were significantly higher in Group 1 and 2 compared with Group 3 (49.1.+-.37.5/20.7.+-.17.6 vs 2.4.+-.1.1pg/ml, p=0.0008/0.0012). Serum IL-10 levels were also significantly higher in the fatal group compared with the survival group with myocarditis (74.0.+-.27.0 vs 16.4.+-.8.8pg/ml, p=0.003). Conclusions. Serum IL-10 levels on admission can be used to predict subsequent cardiogenic shock requiring MCSS and mortality of fulminant myocarditis patients. (author abst.) |
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