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The Roles of Cytokines as Inflammatory Mediators and Anti-cytokine Therapy

Accession number;05A0313186

Title;The Roles of Cytokines as Inflammatory Mediators and Anti-cytokine Therapy

Author; ISHIKAWA TETSUYA (Aichi Medical Univ., Hospital, JPN) KAKUMU SHIN'ICHI (Aichi Medical Univ., Hospital, JPN)

Journal Title;Japanese Journal of Intensive Care Medicine

Journal Code:Z0581B

ISSN:0389-1194

VOL.29;NO.2;PAGE.93-101(2005)

Figure&Table&Reference;FIG.3, REF.25

Pub. Country;Japan

Language;Japanese

Abstract;Excessive host immune responses against the infected or target-loaded hepatocytes may be the key mechanism of massive livernecrosis in the fulminant hepatitis. And there are accumulating evidences that cytokines are involved and play important roles in this mechanism as the inflammatory mediators. Both in the hepatitis model of hepatitis B virus-transgenic mouse and in the hepatitis model of mouse or rat administerd with Propionibacterium/LPS, TNF-.ALPHA. and IFN-.GAMMA. are suggested to be key cytokines that cause severe liver injury. Furthermore, it is reported that the production or the expression levels of cytokines are elevated both in the serum and in the liver of the patients with fulminant hepatitis. Thus anti-cytokine therapy, such as anti-TNF-.ALPHA. and anti-IFN-.GAMMA. therapy may be the promising candidates for the treatment of fulminant hepatitis and need to be investigated further. (author abst.)

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