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Accession number;05A0313187
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| Title;Involvement of Autoimmunity in Fulminant Hepatitis and its Immunosuppressive Treatment |
| Author;
NISHIHARA TOSHIHARU
(Kochidai Shokakibyotaigaku)
AKIZAWA NAOAKI
(Kochidai Shokakibyotaigaku)
IWASAKI SHINJI
(Kochidai Shokakibyotaigaku)
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Journal Title;Japanese Journal of Intensive Care Medicine
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Journal Code:Z0581B
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ISSN:0389-1194
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VOL.29;NO.2;PAGE.103-107(2005)
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| Figure&Table&Reference;TBL.2, REF.6 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Involvement of autoimmunity and immunosuppressive therapy for fulminant hepatitis Autoimmune hepatitis (AIH), a relative rare disorder preponderant in female patients that can present at any age, is chronic active hepatitis with tissue autoantibodies and hypergammaglobulinemia. There are no pathognomonic features, but the presence of antinuclear and smooth muscle antibodies or liver-kidney microsomal antibodies together with typical histological feauteres in liver biopsy allows the diagnosis with good confidence. Hepatic failure in acute phase of AIH is rare, but is frequent in AIH with liver-kidney microsomal antibodies. Its diagnosis relies on the exclusion of viral, metabolic, genetic and toxic etiologies of chronic hepatitis or hepatic injury. Corticosteroid therapy is effective in most patients, but some are refractory to it and extenstive liver support is needed in intensive care units. Relapses after initial treatment responses are frequent, but in the majority of patients the disease can be controlled using sufficient amount of immunosuppressants. (author abst.) |
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