Cases who achieved improvement in blood glucose control and QOL after switching to NovoRapid 30 Mix
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Accession number;05A0483227
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| Title;Cases who achieved improvement in blood glucose control and QOL after switching to NovoRapid 30 Mix |
| Author;
OGAWA SUSUMU
(Tohoku Univ., Sch. of Med.)
TAKEUCHI KAZUHISA
(Tohoku Univ., Sch. of Med.)
KATO TARO
(Tohoku Univ., Sch. of Med.)
NAKO KAZUHIRO
(Tohoku Univ., Sch. of Med.)
ITO SADAYOSHI
(Tohoku Univ., Sch. of Med.)
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Journal Title;Journal of Clinical Therapeutics & Medicines
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Journal Code:Y0906A
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ISSN:0910-8211
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VOL.21;NO.5;PAGE.529-535(2005)
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| Figure&Table&Reference;FIG.3, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In three type-II diabetic patients in whom biphasic human insulin preparations such as 30R and 50R (regular insulin + NPH) failed to control their blood glucose, improvement in the blood glucose control and QOL was achieved by switching to NovoRapid 30 Mix (30 Mix), a biphasic insulin analog preparation (ultrarapid acting insulin analog + intermediate acting insulin analog). We investigated the characteristics of these patients and of each insulin preparation prescribed. The characteristics common to these patients were high blood glucose level after breakfast and dinner but low level before and after lunch, leading frequently to hunger sensation and hypoglycemia. This was attributed to the overlapping actions, during the time around lunch, of R (regular) insulin and N (NPH) insulin in 30R or 50R injected before breakfast. With 30 Mix, there is little or no overlapping time period for the actions of ultrarapid-acting insulin analog (insulin aspart (IAsp)) and the intermediate-acting insulin analog (crystallized protamine insulin aspart). The increase in blood glucose level after breakfast was suppressed by IAsp, while hypoglycemia around lunch time occurred less frequently. Hypoglycemia after lunch cannot be predicted by the measurement of blood glucose level before each meal alone, and is often compensated for by snacks taken between meals and overlooked. If patients being treated with a biphasic human insulin preparation such as 30R and 50R fail to achieve satisfactory control of blood glucose level and body weight, and postprandial blood glucose measurement shows results similar to those described above, we recommend switching to 30 Mix as an option. (author abst.) |
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