Profile of memory T-cell.
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Accession number;05A0266883
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| Title;Profile of memory T-cell. |
| Author;
TAKAGI ATSUSHI
(Apottojapan)
TAMAI HAJIME
(Eikobyoin)
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Journal Title;Modern Medical Laboratory
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Journal Code:Z0084B
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ISSN:0301-2611
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VOL.33;NO.2;PAGE.124-125(2005)
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| Figure&Table&Reference;FIG.1, REF.2 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The formation and works of naive T-cell, memory T-cell and cytotoxic T-cell are outlined. T-cells born in the bone marrow differentiate to naive T-cells in the thymus, and shift in search of the antigen to the lymph node. Here, the lymph node produces chemokine SLC, and the naive T-cells express SLC receptor CCR7. The lymph node expresses GlyCAM-1, a ligand of secletin as an adhesive molecule for naive T-cells. The naive T-cells which reached the lymph node by the above induction, mature to memory T-cells and cytotoxic T-cells, presented with antigens. As naive T-cells express CD45 in RA-type, and memory T-cells and cytotoxic T-cells express CD45 in RO-type, it is possible to discriminate them. Afterwards, the cytotoxic T-cells abandon CCR7, and shift to the peripheral tissue, expressing integrin, a new adhesive molecule. On the other hand, memory T-cells stay in the lymph node, while expressing CCR7, and wait for coming antigens. |
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